This article (
https://www.hindawi.com/journals/isrn/2011/369573/) discusses some relevant issues regarding
genetically modified organisms (GMOs).
-Genetic Contamination/Interbreeding
-Competition with Natural Species
-Increased Selection Pressure on Target and Nontarget Organisms
-Ecosystem Impacts
-Horizontal Transfer of Recombinant Genes to Other Microorganisms
-Unpredictable and Unintended Effects
This is a comprehensive discussion on the ethics of
genome editing -
https://ec.europa.eu/info/sites/def...ics_of_genome_editing-opinion_publication.pdf
It’s very long & detailed but just scan it for some relevant headings & read just enough to understand the key concepts relevant to your query.