Hi Everyone!!
I have question on choosing solvents for organic reactions. Why do we use certain solvent for a particular reaction instead of others? Example :
1) Protection of COOH group : Benzyl alcohol + threonine --> Benzene was used as solvent. Why not toluene or DMSO or DMF??
2) Protection of OH group using TosCl. DMF is used as solvent. Why not DMSO?
So in general, what are the factors affecting the choice of solvent in a particular reaction? Do we account for these factors.. :
1) solubility of solutes in the solvent : non-polar solutes dissolve in Non-polar solvents
2) the heat capacity of solvent? since esterification is endothermic and we need heat for the reaction to proceed, so we need solvent with high heat capacity so that it can hold heat energy and transfer to the reactants??
gosh, i'm confused! someone help me please!! hehe =)
I have question on choosing solvents for organic reactions. Why do we use certain solvent for a particular reaction instead of others? Example :
1) Protection of COOH group : Benzyl alcohol + threonine --> Benzene was used as solvent. Why not toluene or DMSO or DMF??
2) Protection of OH group using TosCl. DMF is used as solvent. Why not DMSO?
So in general, what are the factors affecting the choice of solvent in a particular reaction? Do we account for these factors.. :
1) solubility of solutes in the solvent : non-polar solutes dissolve in Non-polar solvents
2) the heat capacity of solvent? since esterification is endothermic and we need heat for the reaction to proceed, so we need solvent with high heat capacity so that it can hold heat energy and transfer to the reactants??
gosh, i'm confused! someone help me please!! hehe =)