http://www.smh.com.au/news/national/differences-in-intelligence-linked-to-two-dna-regions/2005/07/24/1122143730144.html said:
Scientists are a step closer to a genetic test for intelligence after a study of Australian teenagers identified two regions of DNA linked to performance in IQ tests.
Nicholas Martin, of the Queensland Institute of Medical Research, said between 40 and 80 per cent of the variation in intelligence between people was estimated to be due to genetic factors.
Researchers had generally assumed that hundreds of genes would be involved, each with a small effect, which would make them extremely difficult to find. "We thought: 'That may be true, but we have the ability to detect genes of large effect so we may as well have a look for them,"' Professor Martin said.
His team used a technique called genome-wide linkage scanning to analyse all the DNA of 725 teenagers from 329 Australian families. Non-identical twins and pairs of siblings who had very different IQ scores were found also to have significant differences in two small regions of DNA, one on chromosome two and one on chromosome six. To confirm the findings, Dutch researchers conducted a similar study on 225 people. The two teams' results were published in the American Journal of Human Genetics.
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AdvertisementProfessor Martin said the two regions contained hundreds of genes and a lot more work was needed to identify the ones influencing intelligence. "We have reduced the search from a needle in a haystack to a needle in a hay bale," he said.
The research could improve scientific understanding of intellectual disorders such as autism, dyslexia and attention deficit hyperactivity. "Finding new therapies for intellectual disability would have great social benefit," Professor Martin said.
If a genetic test for intelligence was developed there was a risk, as with any new technology, that it could be misused to discriminate against individuals, he said. In democratic countries, society would decide on appropriate uses, but he thought it was unlikely that Australians would allow genetic testing of IVF embryos to select those with a predisposition for high intelligence.
But Ian Findlay, of Brisbane company Gribbles Molecular Science, said he thought there would be pressure for screening of embryos, even though a test would be imprecise.
Some parents may want to test young children to identify those academically inclined so they could push them in that direction, Professor Findlay said. "Parents are already very competitive about getting their children into schools. They want the best for them."
The region on chromosome two was found to overlap with a stretch of DNA linked to autism, and the region on chromosome six overlapped with an area implicated in dyslexia.